664-665 / 2605
Protons in pediatric malignancies
Dosimetrical evidences
AUTHOR [Ref]
(Year)
SITE / TUMOUR TYPE
TOTAL DOSE
(CGE)
RÉSULTS
Miralbell, R [18 ]
(1997)
Medulloblastoma
(supra tentorial)
30 Brain
±
10 ventricles
P:
æ
risk IQ decline
Miralbell, R [19 ]
(1997)
Medulloblastoma (spine)
30
P:
æ
dose vertebral body, heart, liver, thyroid, gonads
Fuss, M [20 ]
(1999)
OpYc gliomas
50.4
P:
k
conformaYon large tumours,
k
protecYon chiasm, contralat ON,
hypophysis, temporal lobes
Lin, R [21 ]
(2000)
Posterior fossa
54
P
k
sparing cochlea, temporal lobes
Miralbell, R [22 ]
(2000)
RMS orbit,
NHL, meningiomas
30-54
IMPT:
k
sparing lens/cornea
Hug, EB [23 ]
(2001)
Neuroblastoma
34.2
P:
k
sparing
homolat/contralat kidneys,
liver, spinal cord
Miralbell, R [18 ]
(2002)
Medulloblastoma,
RMS PM
36-50
æ
risk K2
St Clair WH [24 ]
(2004)
Medulloblastoma
23 CS/54 PF
P:
k
sparing cochlea,
hypophysis, heart…
Yuh, GE [25 ]
(2004)
Medulloblastoma
36 CS/
54 PF
P
m
dose cochlea, vertebrae, thorax, abdomen,
m
myelosuppression
Krengli, M [26 ]
(2005)
ReYnoblastoma
40 ± 6
P:
k
sparing orbit,
Contralateral eye,
brain, hypophysis
Lee, CT [ 27]
(2005)
Medulloblastoma, 1,
reYnoblastoma, 2, pelvis3
23-54
P:
k
sparing1: cochlea, hypophysis; 2: orbit, lens; 3:ovaries, iliac
bone
Merchant, TE [28]
(2008)
OpYc glioma 1,Ependymoma PF2,
Medulloblastoma3, Craniopharyngioma4
Variable
P:
k
sparing 1,2 : temporal lobes,
3 :cochlea, 4 :
æ
risk IQ decline