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Proton Therapy was pioneered by Shipley and associate at MGH
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Phase I/II study initiated in 1979 and published in JAMA
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Limited to locally advanced disease, T3-T4 clinical stage
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Proton Therapy as a boost only, given via perineal field
Therapeutic Results - Proton Therapy: Historical series
Shipley et al, Jama, 241: 1912, 1979