922-923 / 2605
• Phase II randomized study: 92 patients with localized prostate cancer
STUDY
ARMS
protons at 66 Gy in 20 fractions
carbon ions at 66 Gy in 20 fractions
• CTV (prostate and the inferior 2/3 of seminal vesicles plus a margin of 2 mm
• PTV : CTV plus 7 mm in lateral direction (beam direction) and 5 mm anterior-posterior
and inferior-superior direction
Therapeutic results
Acute Toxicity and Quality of Life in Patients
With Prostate Cancer Treated With Protons or
Carbon Ions in a Prospective Randomized Phase
II Study - The IPI Trial
Hypofractionation using either carbon ions or protons results in comparable acute
toxicities and QoL parameters (wih carbon ions was lower but not statistically
significant).
Of note, due to the occurrence of gel in the rectal wall and the consecutive occurrence
of 2 rectal fistulas, the authors stopped using the insertion of spacer gel.
Habl et al, IJROBP, 2016