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© 2012 AOAC INTERNATIONAL

G

UIDELINES

FOR

S

TANDARD

M

ETHOD

P

ERFORMANCE

R

EQUIREMENTS

AOAC O

FFICIAL

M

ETHODS

OF

A

NALYSIS

(2012)

Appendix F, p. 6

Table A1. Performance requirements

Classifications of methods

a

Quantitative method

Qualitative method

Identification method

Main component

b

Trace or contaminant

c

Main component

b

Trace or contaminant

c

Parameter

Single-laboratory validation

Applicable range

Bias

d

Precision

Recovery

Limit of quantitation (LOQ)

Applicable range

Bias

d

Precision

Recovery

LOQ

Inclusivity/selectivity

Exclusivity/cross-reactivity

Environmental interference

Laboratory variance

Probability of detection

(POD)

e

Inclusivity/selectivity

Exclusivity/cross-reactivity

Environmental interference

Laboratory variance

POD at AMDL

f

Inclusivity/selectivity

Exclusivity/cross-reactivity

Environmental interference

Probability of identification

(POI)

Reproducibility

RSD

R

or target

measurement

uncertainty

RSD

R

or target

measurement

uncertainty

POD (0)

POD (c)

Laboratory POD

g

POD (0)

POD (c)

Laboratory POD

g

POI (c)

Laboratory POI

a

See Annex B

for additional information on classification of methods.

b

≥100 g/kg.

c

<100 g/kg.

d

If a reference material is available.

e

At a critical level.

f

AMDL = Acceptable minimum detection level.

g

LPOD = CPOD.