354 / 884
Biopsies: at random - systematic
Chance of hitting tumor per biopsy=15-20%
Gleason score: poorly reproducible
Biopsy agreement with prostatectomy: (n=1670)
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Gleason 5-6 undergrading: 35%
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Gleason 8-10 overgrading: 35%
PSA
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Suspected linear relation with amount of tumor cells
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Irreliable due to leakage, often false positive
Conclusion: Literature contains probably higher Gleason scores too
Risk groups – Individual tumor characteristics: