372 / 884
Toxicity grading:
• Severe toxicity (grade > 3) most important
• Urinary Grade > 3 toxicity rates:
– Acute urinary retention:
+ 10% (5-34%) = highest incidence
– Urinary incontinence:
+1.5% (0-17%)
– Urinary bother:
+ 1-3%
– Hemorr. cystitis
<<<1%
– Infection
<<<1%
– Fistula
<<<1%
• Rectal Grade > 3 toxicity rates: <1%
• Erectile dysfunction:
complicated, baseline function matters
Anderson et al. Urol 2009;74:601-5
Gore et al. JNCI 2009;101:888-92
Bottomley et al. RO 2007;82-46-9
Chen et al. JCO 2009;27:3916-22