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Radiation proctitis - Acute
Pathophysiology
Histopathology findings
•
Transient mucosal atrophy
•
Submucosal oedema
•
Inflammation and infiltration of the lamina
propria with polymorphonuclear leukocytes
and plasma cells
•
In addition, mitotic arrest, karyorrhexis, and
lysis of the crypt and deep epithelial cells