ESTRO Brachytherapy for Prostate Cancer 2018

Liu W, Laitinen S, Khan S, Vihinen

M, Kowalski J, Yu G, Chen L,

Ewing CM,

Eisenberger MA, Carducci MA,

Nelson WG, Yegnasubramanian

S, Luo J, Wang Y, Xu J,

Isaacs WB, Visakorpi T, Bova GS.

Nat Med. 2009 Apr 12. [Epub

ahead of print]

Non metastatic

Metastatic / non lethal

Metastatic / lethal

High-resolution genome-wide single nucleotide polymorphism and copy

number survey

“D

espite common genomic heterogeneity

in primary cancers, most metastatic cancers

arise from a single precursor cancer

cell.”