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The rate of intraprostatic relapses after primary EBRT is still not

negligible:

• 20-40% (20-25.000 failure/year)

• 60% - 72% of patients with negative metastatic workup and

rising PSA after RT will have positive prostatic biopsies

Zelefsky et al. Int. J. Radiat. Biol. Phys. 1998

Zagars et al. Int. J. Radiat. Biol. Phys. 1995

Pollack et al. Int. J. Radiat. Biol. Phys. 2002

Crook et al. Cancer. 1997

Alongi et al. CROH. 2013