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Discussion: Clinical Relevance

Should we measure intra-fraction motion?

Yes, at planning in order to individualize the safety margin

And if necessary to reduce the motion amplitude with compression

Should we correct for intra-fraction motion?

The penumbra is more sharp in liver than in lung

Amplitude has an effect on the margin

Still systematic uncertainties dominate the required margin

Should we correct for inter-fraction motion?

YES!

Should we adapt the treatment plan?

First solve issues mentioned above