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A short history of intracranial SRS
•
1908:
!
Robert Henry Clarke and Victory Horsley:
Stereotactic
technique based on the reproducibility of the relationships
between landmarks on the skull (external auditory canals,
midline) and anatomical structures within the brain
•
1950s:
!
Lars Leksell:
Experiments with 250 kV rotating X-ray source (1951) and
stereotactic proton therapy (1955)
•
1967:
!
Lars Leksell:
Gamma-knife radiosurgery using
60
Co-sources for treatment of
functional disorders
•
1980s:
!
Oswaldo Betti and Frederico Colombo:
CT-localization and linac-based SRS
Betti
et al.