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A randomized trial comparing preoperative
chemotherapy plus surgery with surgery alone in
patients with non-small-cell lung cancer.
Rosell R,
NEJM 1994
Median survival was 26 months in patients treated
with chemotherapy plus surgery, as compared with 8
months after surgery alone
A randomized trial comparing perioperative
chemotherapy and surgery with surgery alone in
resectable stage IIIA non-small-cell lung cancer.
Roth JA JNCI 1994
Estimated 2- and 3-year survival rates were 60% and
56% for perioperative chemotherapy patients, and
25% and 15% after surgery alone, respectively.
60 pts
60 pts