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SABR & pulmonary interstitial changes

260 consecutive SABR cases with primary lung cancer

Pre-treatment pulmonary interstitial fibrosis (PIF) group (n=18);

non-PIF group (n=242)

Grade ≥2 radiation pneumonitis in 9 (

50.0%

) of PIF group

versus 14 (

6.7%

) in non-PIF group

3 patients with grade 5 RP were all in PIF group.

CONCLUSION:

On multivariate analysis, the presence of PIF was the only

significant predictive factor of ≥grade 2 pneumonitis

Yoshitake T, Anticancer Res 2015