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All HRF’s associated with local recurrence (p<0.01). Best

individual predictor was opacity enlargement after 12-

months

(100% sensitivity, 83% specificity, p<0.001).

Odds of recurrence increased 4-fold for each additional

HRF detected.

Presence of ≥3 HRFs highly sensitive and specific for

recurrence (both >90%).

Fibrosis or recurrence after SABR?

Huang K, Radioth Oncol 2013