SBRT2015

Metastases or new primary

Array CGH: Tumor DNA is differentially labeled to reference (wild

type) DNA, resulting in a gains and losses pattern for each tumor.

50 nanograms of DNA/sample is sufficient.

Different CGH patterns

prove

lack of clonality

; similar CGH

patterns denote clonality; up to 10% have inconclusive findings

Panel showing serial CT scans and array CGH in patient

Van Iersel M, Lung Cancer 2015