835 / 1138
• (Very) high rates of gastrointestinal toxicity DESPITE short FU
• Difficult (impossible) sparing of duodenum
SBRT for locally advanced PC
SBRT for pancreatic cancer
Study
Patients
Toxicity
Hoyer 2005
Phase II
22
5 cases with severe GI tox
Koong 2005
Phase II
17
2/17 acute G3 GI
Schellenberg
2008
Phase II
16
Late:
5x G2 ulcers
1x G3 duodenal stenosis
1x G4 duodenal perforation
Schellenberg
2011
Phase II
20
3x G2 ulcers
1x G4 duodenal perforation
ESTRO SBRT Course 2014 - Emerging SBRT indications
10