SBRT2015

Hypofractionation ???

Rational

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Extremely slow average growth kinetics:

median Tpot of 42 days

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PSA doubling times: <12 months - >5y

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LI < 0.6%

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Alpha/beta : 1.5 to 5 Gy

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Such slow growth rate is typical for late-responding tissues

Brenner et al.

Int J Radiat Oncol Biol, 43, 1095-1101, 1999