Table 28.14-6
Empirical Risks for Selected Mental Disorders
Schizophrenia
Bipolar Disorder
Unipolar Major
Depressive Disorder
Schizoaffective
Disorder
Obsessive-
Compulsive
Disorder
Panic
Disorder
Generalized
Anxiety
Disorder
Alcohol
Dependence
Phobia
Anorexia
Nervosa
ADHD
Men
Women
Men Women
Affected relative
General
population
1%
a
0.8%–
1.6%
b
,
c
,
d
,
e
1%–
15%
b
,
c
2%–
23%
b
,
c
0.5%–
<
1%
b
,
c
,
d
1.5%–3%
a
,
p
1.5%–
3.5%
a
,
n
3.5%
a
14%
a
3%
a
4%–11%
a
0.1%
a
3%–5%
f
First degree
(pooled)
9%
a
5%–20%
b
,
c
,
e
9%
a
18%
a
1%–10%
b
,
c
,
d
17%–25%
a
,
p
15%–
25%
a
,
n
20%
a
27%
a
5%
a
12%–
31%
a
5%–10%
a
15%–60%
q
Siblings
9%–16%
d
,
i
,
j
,
k
5%–
20%
b
,
c
,
e
,
h
,
i
5%–
30%
b
,
c
,
h
,
i
5%–
30%
b
,
c
,
h
,
i
—
25%–35%
l
—
—
— — —
—
17%–25%
g
Parent
5%–13%
g
,
i
,
j
,
k
,
o
15%
c
,
d
,
e
,
h
,
m
7%–
19%
h
,
i
7%–
19%
h
,
i
—
25%–35%
l
—
—
— — —
—
—
Both parents
45%
h
,
i
50%–75% for
affective
disorder
b
,
d
,
h
,
i
—
—
—
—
—
—
— — —
—
—
Second degree
(pooled)
2%–6%
h
,
i
5%
h
—
—
—
—
—
—
— — —
—
3%–9%
q
Uncle/aunt
1%–4%
i
,
j
—
—
—
—
—
—
—
— — —
—
—
Nephew/
niece
2%–4%
i
,
j
,
o
—
—
—
—
—
—
—
— — —
—
—
Grandparent 2%–8%
i
,
j
—
—
—
—
—
—
—
— — —
—
—
Half-sibling 4%
i
,
j
—
—
—
—
—
—
—
— — —
—
—
Third degree —
—
—
—
—
—
—
—
— — —
—
—
First cousin
2%–6%
i
,
j
—
—
—
—
—
—
—
— — —
—
—
Risks for
additional
mental
disorders
Spectrum
disorders
(schizoaffective
disorder,
schizotypal
personality
disorder,
paranoid
personality
disorder);
unipolar
and major
depression
Unipolar
disorder,
substance
dependence,
schizoaffective
disorder,
cyclothymia,
anxiety
disorder,
FDR; RR
any affective
disorder:
∼
20%–30%
Anxiety disorders, alcohol
dependence, dysthymia,
ADHD
Schizophrenia,
other
psychotic
disorders,
bipolar
disorder,
unipolar
depression,
FDR; RR
mood or
psychotic
disorder
∼
30%
Tourette’s
disorder
chronic
tics,
unipolar
depression
—
Unipolar
major
depression
—
—
—
Unipolar
depression,
bipolar
disorder,
oppositional
disorder,
conduct
disorder,
anxiety
disorders
(
continued
)
905
