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High Doses to Small V:
Things to keep in mind
0
EQD2 [Gy]
Volume [%]
100
10
20
30
40
50
60
70
80
90
10
80
90
100
20 30 40 50 60 70
V
40Gy
= 94 %
V
50Gy
= 75 %
V
60Gy
= 10 %
BT
EBRT
EBRT + BT
10
20
30
40
50
60
70
80
90
100
BT
EBRT
EBRT + BT
0
10 20 30 40 50 60 70 80 90
V
40Gy
= 94 %
V
50Gy
= 42 %
V
60Gy
= 49 %
EQD2 [Gy]
Volume [%]
45 Gy EBRT + 4 x BT (EQD2=85 Gy)
45 + 15 Gy EBRT + 2 x BT (EQD2=85 Gy)
Example from ICRU 89 Report, p. 113.
Intermediate- &
Low- D Volumes
Clinical effects of
D
2cm3
and D
0.1cm3
High - D Volumes
2 Regimens with identical D2
cm3
different effects expected due to different EBRT / BT