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2

Paradox of standard point A dose prescription

50

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140

0 10 20 30 40 50 60 70 80 90 100 110

Volume HR CTV, cm

3

HR-CTV D90 standard

Violation of OAR constraint

K Tanderup et al, Radiother Oncol 2010

Point A dose = 85Gy

Standard loading pattern