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Totally delivered D (“waste D”)

Timing

of Nodal Boost

Sequential Boost

Simultaneous Integrated Boost

GTV Regression can be considered

+

-

Totally administered D

Overall Treatment Time

CTV-T & CTV-N move differently

+

+

-

i.e.:

PTV-N:

16 Gy in 8 fx

PTV-E: 45 Gy in 25 fx

PTV-N: 55 Gy in 25 fx (True pelvis)

57.5 Gy in 25 fx (Outside True p.)

PTV-E:

45 Gy in 25 fx

i.e.:

(EMBRACE 2 Study protocol)

Nodes shrink- Replanning

-

Courtesy Primoz Petric