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Follow-up: The patients were followed every 3 months during the first two
years. The follow-up study always included physical examination, cytology
every 6 months, MR every 6 months and CT annually. From years 3 to 5 the
consultations were made every 6 months, with MR every year. After year 5
the follow-ups were carried out annually. The visits were alternated
between the Gynaecology Department and the Brachytherapy Unit.
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Statistical analysis : General digestive, urinary and rectal toxicity were
reported according to the Common Terminology Criteria for Adverse
Events (CTCAE) v4 scale. T de Student was used to compare median of
doses between groups of toxicity grade 0-1 versus grade 2-3. Kaplan-Meier
test was used to calculate survival curves. Log rank test was used to
compare prediction factors in survival