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A Systematic Review and Meta-analysis
J. A Green - Confessions
• In our review, 68% of patients overall were stage I
and II;
• Although an overall reduction in the risk of death with
chemo-radiotherapy was shown,
Gillian Thomas
advised
“
caution in extrapolation of the results to advanced
stages.
Our exploratory analysis
shows less benefit
and
more heterogeneity
in studies with a high
proportion of advanced-stage patients than in those
with a low proportion of such patients”