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IR CTV :

Integrates GTV

at the time of diagnosis

Always includes HR-CTV

In case of major response :

includes safety margins with regard to initial size GTV

Intent : 60 + Gy total dose to CTV in definitive

radiotherapy in advanced disease

Dose comparable with dose to the 60Gy isodose (ICRU

recommendations)

CTV for the primary tumor (CTV-T)