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Uncertainties related to

1. Source calibration

2. a) Dose calculation in water

~ 1,5 %

~ 4 %

b) Systematic effects

3. Accuracy of afterloader performance

(time/spatial distribution)

4. Imaging (localisation, volume interpolation,…)

Mainly site specific

up to 10 %

~ 2 %

5 %

5. Contouring

6. Variations at patient level (inter- and intrafraction

variations, organ movement/swelling)

x %

up to ~50%