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Treatment-related carotid blow-out syndrome was observed in 8 patients
(17.8%), 7 (15.2% of whom died of bleeding from carotid.
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Bleeding was not statistically significantly related to tumor volume (p
=0.682), response to treatment (p = 1.00), sex (p = 0.698), or time elapsed
between SBRT and previous radiotherapy (p = 0.113). However, when the
dose received by the carotid artery was grouped as <100% of the
prescribed dose, a significant relation was observed between the carotid
artery dose and bleeding (p = 0.021). None of the patients with carotid
artery dose <100% experienced carotid blow-out syndrome.
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Bleeding occurred only in patients whose carotid artery walls were
circumscribed by the tumor with a degree of >180 (p = 0.073).
Cengiz et al. IJROBP 2011