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Patients treated 1.8–2-Gy daily fractions or 1.2-Gy twice daily fractions rate of CBS
was 1.3%.
Patients treated with 1.5-Gy twice daily fractions over alternating weeks or with
delayed accelerated hyperfractionation received concurrent chemotherapy, and the
rate of CBS was 4.5% (p = 0.002).
Intensity-modulated radiation therapy (IMRT) series reported bleeding rates of 0–3%.
6.6% of CBS ratio in SBRT seems to be higher than conventional Fraction.
Yamazaki et al. radiotherapy and oncology 2013
Careful attention should be paid to the occurrence of CBS if the tumor is located
adjacent to the carotid artery. The presence of skin invasion at CBS onset is
ominous sign of lethal consequences.