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HDR- ICBT: late complications
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Clinical Data
HDR vs LDR
Review literature *
(Fu and Phillips 1990)
G2-4 12 % 18 %
Meta-analysis 17 068 pts
(Orton 1991)
G3-4 2.2% 5.3% p<0.001
Randomised Phase III
(Patel 1994)
G1-4 6.4% 19.9% p<0.001
G3-4 0.4% 2.4% p> 0.05
* majority Fx 7.8 Gy to point A