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Introduction on Dose Optimization
All developed methods and algorithms in the past
20 years have been influenced by the following factors:
A detailed 3D description of the implanted catheters is pre-assumed
and is mandatory (reconstruction, SDPs)
Is a detailed 3D description of the relevant anatomy (Targets, OARs)
available (3D anatomy model)?
Can the wished dose distribution be expressed in numbers?
(Computers and Algorithms understand only numbers not “thoughts”)
Chronological Order
Can we find a mathematical formulation combining the “wishes” and
the Source stepping ability (dwell times, step & shoot) which can then
be used to automatically set-up the Source stepping in the catheters
(dwell times), to solve the inverse problem?
…..