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B-cell
Depletion
Immune
Syndromes
Neuro-
toxicity
▪
Targeting of normal B-cells
▪
Duration correlates with persistence
▪
IVIg can be given to pts with persistent hypo-
gammaglobulinaemia
▪
No serious infectious complications arising following this in
trials reported to date
▪
Obtundation, cranial nerve palsy, aphasia, seizures
▪
Not related to presence of CNS disease
▪
CSF pleocytosis – CAR+ and CAR- T cells
▪
Self-resolves within weeks
CAR19 toxicity
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