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Efficacy of RT and anti-PD-L1 combination is CD8
+
T cell dependent
CD49b
CD8a
NT Depleted
CD49b
CD4
CD49b
CD8a
0
25
50
75
100
0
20
40
60
80
100
NT
5x2Gy RT +
B7-H1 10mg/kg 3qw
5x2Gy RT +
B7-H1 +
CD8 mAb
5x2Gy RT +
B7-H1 +
CD4 mAb
5x2Gy RT +
B7-H1 +
AGM1 mAb
Time after tumour
innoculation (days)
Percent survival