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Blocking immune
checkpoints may promote
endogenous antitumour
activity
►
PD1: Inhibitory receptor
on activated T-cells, B-
cells, NK and myeloid
cells. Inhibition of T-cell
activation when engaged
by ligands (PDL1/2)
►
PD1 expressed on T-cells
when exposed to tumour,
and associated with
exhaustion. Blocking can
restore function
Ribas A. N Engl J Med 2012;366:2517-2519.
Exhausted T-cells