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General principles of management
•
Early stage:
–
Low-grade
:
curative
RT
–
High-grade
:
CMT
if RT feasible. Full course chemo alone if not.
•
Tolerability of chemo
•
Response to chemo
•
Morbidity of RT
•
Suitability for future salvage
•
Advanced stage:
–
Low-grade: systemic Rx ±
RT
for local control
–
High-grade: systemic Rx ± consolidation
RT
to sites of EN disease