1586 / 1631
3-year incidence
of CNS relapse
% (95%CI)
Unadjusted
hazard ratio
HR (95% CI)
1.7 (0.9-3.5)
1.0 (ref)
4.0 (2.5-6.4)
3.0 (1.3-6.7)
4.8 (2.4-9.4)
3.4 (1.3-8.5)
12.8 (6.6-24.0)
8.1 (3.1-20.9)
32.1 (20.1-48.8)
22.0 (9.0-53.6)