221 / 1631
Cardiovascular disease after therapy for HL:
A detailed analysis of 9 collaborative EORTC-LYSA trials
3
1
1.5
2
2.5
3
0
5
10
15
20
25
30
35
40
Hazard ratio
A
Increase in mean heart dose (Gy)
B
1
1.5
2
2.5
3
0
100
200
300
400
500
1
1.5
2
2.5
0
5
10
15
20
25
30
35
40
Hazard ratio
Increase in mean heart dose (Gy)
Increase in cumulative dose of anthracyclines (mg/m
2
)
Hazard ratio
B
Maraldo et al, Lancet Hemat 2015
The mean heart radiation dose and the cumulative dose of anthracyclines were significant predictors of
CVD, with an increase in hazard rate of 1·5% (95% CI: 0·6–2·4%) per 1 Gy increase in mean heart dose
and 7·7% (95% CI: 2·1–13·7%) per 50 mg/m2 increase in cumulative anthracycline dose.