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Surviving Fraction MCF7

(breast cancer)

1.0

0.1

0.01

0.001

0.00001

0.0001

2 4 6 8 10

Dose (multiples of IC

90

)

Methotrexate

Vincristine

Ara-C

Cyclophosphamide

Carboplatinum

Melphalan

Thiotepa

BCNU

Correlation of dose and efficacy

Cytostatic drugs

in vitro