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2

2 x eBEACOPPesc

FDG-PET-2 positive:

End of therapy AND residual disease ≥ 2.5 cm AND positive PET: RT

4-6x

BEACOPPesc

4-6x

BEACOPPesc

2x

BEACOPPesc

FDG-PET-2 negative:

2 x eBEACOPPesc

Centrally reviewed PET/CT

Arm C

Arm D

Final analysis of the GHSG HD18 trial

GHSG HD18 trial

PET-guided therapy of advanced-stage HL