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Pathology of cHL: rare malignant
Reed-Sternberg cells within an
extensive inflammatory/immune cell
infiltrate.
Genetic analyses: frequent 9p24.1
amplification with upregulation of
PD-1 ligands and JAK2.
Hypothesis: cHL may have a gene-
tically driven dependence on PD-1.
PD-1 Blockade in HL
Background
Juszczynski et al; PNAS 2007, 104: 13134
Green et al; Blood 2010, 116: 3268; Chen et al; Clin Cancer Res 2013, 19:3462