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Role of RIT in Follicular lymphoma
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RIT simple and effective treatment; most active single drug
apprach in NHL, unique mechanism of action
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Effective (high response rate, durable remission) and underused single
treatment in relapsed and rituximab refractory disease (131I Tositumomab,
90Y Ibritumumab tuxetan)
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Phase II data as single agents Zevalin RIT in untreated follicular lymphoma
show high response rates and durable remission
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Patients in Phase 3 randomised
90
Y-ibritumomab arm had a greater than 5-
year advantage in time to next treatment in FIT trial as consolidation
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Novel Radioimmunconjugates are being developed but pathways to
registration and routine clinical use are challenging.