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RELEVANCE Study Design

(Rituximab and LEnalidomide versus Any ChEmotherapy)

1

st

line

FL

N=1000

R

R

2

R + Chemo

R

2

Maintenance

Rituximab Maint.

R+Chemo:

Investigator’s choice of R-CHOP, R-CVP, BR

Lenalidomide 20mg for 6 cycles, then 10mg if CR