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Constraints, why are they so difficult in
lymphomas?
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The location of the target varies, may be located anywhere in the body
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The doses that we need are much lower than in solid tumours
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Acute toxicity is not a major problem
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Most patients may expect to become long-term survivors
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Late effects are a major issue
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Even the low doses used for lymphoma treatment cause serious late
effects, there is no safe dose level