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Most AEs were grade 1 or 2.

1

There were low rates of grade

3 and 4 adverse events.

1

The rate of grade 3 bleeding

events was 4.5%, there were no

grade 4 or 5 events

1

The most common infection of

grade ≥3 was pneumonia (6%)

1

Phase II study

Adverse event profile

.

1. Wang M et al. N Engl J Med 2013; 369: 507-516.

Adverse events (AEs) reported in ≥15% of MCL patients

1

* Febrile neutropaenia 2.7%