804 / 1631
SWOG Contributions: Limited Stage DLBCL
• SWOG 8736
– Established CHOP x 3+RT as standard of
care
– Introduced the
stage-adjusted IPI
:
Risk Factors
Age >60
Increased LDH
Stage II or IIE
ECOG Performance
Status ≥ 2
Estimated 5-yr OS in S8736 By Risk
Factors
0-1
82% (95%CI 77-87%)
2
71% (95%CI 60-83%)
3
48% (95%CI 22-69%)
4
0%
(Miller, NEJM 1998)