880 / 1631
CD5 Positive DLBCL
Thakra et al Eur Journal Haematology 2017
Comprises 5-10% of DLBCL cases
Older women, advanced stage, high LDH and extranodal
sites
Most cases of are of the non-GCB type
Rule of Richter’s transformation of CLL and blastoid type
mantle cell lymphoma
Clinical course of de novo CD5+ DLBCL is recognised as
more aggressive than that associated with CD5-DLBCL
Frequent CNS involvement
Using DA-EPOCH-R does not overcome poor prognosis