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Double and Triple Hit…

5% of DLBCL patients

Approx. 60%

BCL2

, 20%

BCL6

and 20%

triple hit

Limited data on

MYC/BCL6

DHL therapy

R-CHOP is inadequate therapy

Do we need to FISH all DLBCL cases?

Low prevalence

Johnson et al. Blood 2009

OS DHL BC Series