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Pixantone
⚫
Phase III open label
Aggressive
Lymphoma*
Relapsed >2 therapies
(inc 1 anthracycline
with response >24
weeks)
LVEF>50%
Vinorelbine 30 mg/m
2
1, 8, 15, and 22 4 weeks
Oxaliplatin 100 mg/m
2
1
3 weeks
Ifosfamide 3000 mg/m
2
1 and 2
4 weeks
Etoposide
100 mg/m
2
1, 2, 3, 4, and 5 4 weeks
Etoposide
50 mg/m
2
Daily for 21 days 4 weeks
Mitoxantrone 14 mg/m
2
1
3 weeks
Gemcitabine 1250 mg/m
2
1, 8, and 15
4 weeks
Rituximab 375 mg/m
2
1, 8, and 15 of
cycle 1 and day 1
of cycle 2
3 weeks
Pixantrone 85mg/m
2
1, 8 and 15
28 days
R
1
o
Endpoint: CR/CRu
2
o
Endpoints: ORR,
PFS, OS
* Exclusion of Burkitt’s,
lmyphoblastic, Mantle,
CNS, HIV related