Zetasizer Helix

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Zetasizer Helix brochure - MRK2127-02 2
 DLS data: Small size change
 Raman data: 2° and 3° structure change
 Combined data: Partial unfolding event
Specifications
DLS light source He-Ne Laser 633nm, Max 10mW
Raman light source Diode Laser 785nm, Max 280mW at the sample
Dimensions (W, D, H) 320 x 600 x 375mm (Zetasizer) 580 x 450 x 200mm (Raman)
Weight 19Kg (Zetasizer) 28Kg (Raman)
Spectral performance 150cm-1 to 1850cm-1 6cm-1 resolution
Protein secondary and
tertiary structural markers
Backbone - amount of α -helix, β-sheet, and random coil
Tyrosine - hydrogen bonding extent, hydrophilic or hydrophobic environment
Tryptophan – indole ring dihedral angle to backbone, extent of cation π interaction, if indole ring is buried
or exposed, hydrophilic or hydrophobic environment
Disulfide – Differentiate conformers, loss of covalent bond
Data collection modes Isothermal incubation, Temperature ramp, Temperature jump, Sample / formulation series
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