ESTRO 36 Abstract Book

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S1000 ESTRO 36 2017
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Website A scored 88 out of 141 or 62.41% on the LIDA tool,
someway less than the other 3 popular patient websites.
Website A scored highly in consistency of layout, search
function and website accessibility, but scored less well for
reliability (1 out of 27). Other issues identified with
Website A included clarity of information and user
interaction. In addition,website A had readability issues,
with some content written at a level higher than advised
by guidelines. This will impede those with low literacy
from effectively using the website.
Conclusion
Website A scored lowest of the four websites as a result of
issues relating to the reliability of the website. This issue
is easy to address, and acting on recommendations from
this research, would bring the website in line with other
recognised cancer patient information websites, in
relation to is important to remember that the
studied websites, while all related to cancer information,
are not directly comparable in that they are not specific
to radiotherapy, the size of the organisation, the traffic
to the site or the country of the sites origin. However steps
can be taken as a result of this study to improve the
usability of Website A, allowing for greater empowerment
of patients through knowledge acquisition which may
ultimately lead to improved clinical outcomes.
EP-1856 The impact of waiting time on survival of Lung
Stereotactic Ablative Body Radiotherapy patients
Y. Tsang1, P. Nariyangadu2, N. Shah3, P. Ostler3, P.
Hoskin 3
1 Mount Vernon Hospital, Radiotherapy, Northwood
Middlesex, United Kingdom
2 Mount Vernon Hospital, Radiotherapy Physics,
Northwood Middlesex, United Kingdom
3 Mount Vernon Hospital, Clinical Oncology, Northwood
Middlesex, United Kingdom
Purpose or Objective
The introduction of Stereotactic Ablative Body
Radiotherapy (SABR) has led to a rapid change in
treatment utilization in elderly patients with early stage
non-small cell lung carcinoma (NSCLC). This study aims to
investigate the impact of waiting time on lung SABR
treatment outcomes.
Material and Methods
A consultant radiographer has been appointed to lead our
institution’s SABR service since April 2014. The post holder
was expected to streamline the patient pathways that still
deliver high quality services but in more resourceful and
innovative ways including radiographer led target volume
delineations and consent.
Between 2011 and 2015, 105 NSCLC patients were treated
with SABR. A retrospective review was done to determine
the relationship between overall survival (OS) and
intervals between decision to treat and treatment start
date (INT). Medians were used to split the distribution of
INT into two groups: below and above median. Survival
curves for each group were compared using a log rank test.
Similar analysis was undertaken comparing patients who
were treated before and after the appointment of the
consultant radiographer.
Results
The median age was 73.9 years (range: 53.0-92.9) and
median follow-up was 30.8 months (range: 14.9-74.6). For
all patients the median OS was 20.7 months (95%CI: 15.4-
26.0) and INT was 1.0 months (range: 0.1-6.9)
respectively. No significant difference in OS was found
between the below and above median groups (p=0.46).
The median waiting time has been shortened from 1.4
months to 0.6 months (p<0.05) since the joining of the
consultant radiographer at our institution although no
effect on OS (p= 0.13) is found.
Conclusion
It’s suggested that the waiting time has been shortened
since the appointment of the consultant radiographer.
However no significant effect on OS has been seen. This is
contrary to published data using conventional
radiotherapy. The short overall time for SABR may be
compensating for the difference in waiting time to start.
The numbers in this study are small and a significant
difference may emerge with a larger cohort.
EP-1857 Radiotherapy impairs on the bonding system
in primary teeth
A. Queiroz1, T. Mellara1, P. Nelson-Filho1, J. Arid1, J.
Romano1, H. Oliveira2, R. Palma-Dibb 1
1University of São Paulo - School of Dentistry of Ribeirão
Preto, Department of Pediatric Dentistry, RIBEIRAO
PRETO, Brazil
2University of São Paulo - School of Medicine of Ribeirão
Preto, Department of Medical Clinics, RIBEIRAO PRETO,
Brazil
Purpose or Objective
When radiotherapy (RT) is performed in the head and neck
region, it could lead to structural alteration in enamel and
dentin that could influence the behavior of the bonding
agents. The present study aimed to evaluate whether the
RT interferes in the bonding o two adhesive systems
(Clearfil SE Bond e Adper TM Single Bond 2) to enamel (E)
and dentin (D) of primary teeth, in different times (before
and after RT).
Material and Methods
Sixty primary molars were cut in a total of 120 fragments
of enamel and 120 of dentin, which after the surface
polishing were randomly divided into 4 groups
(n=30/group): G1 (control) – enamel and dentin without
RT + restorative procedures; G2 - restorative procedures
performed before RT; G3 - restorative procedures
performed after RT; and G4 - restorative procedures
performed 6 months after RT. Each one of the groups was
then divided into 2 subgroups: subgroup A – using the etch-
rinse AdperTM Single Bond 2; and subgroup B – using the
self-etch Clearfil SE Bond. The specimens were irradiated
in dose fractions of 2 Gy, for 5 consecutive days, until
reaching the final dose of 60Gy, in a total of 30 fractions,
during 6 weeks. The restorative procedures were done
using the Z350 composite, and for standardization of the
restorations a matrix was used, so the specimens all
presented 4 mm height and 2 mm of diameter. The
specimens were submitted to the shear bond strength test
(load of 50 kgf and speed of 0.5 mm/minute), the result
was obtained in N and then transformed to Mpa. The
fracture pattern was analyzed in a confocal microscopy
(MC). Five specimens of enamel and 5 of dentin were
chosen to the morphological analyzes also by MC, those
specimens were evaluated every 10 Gy. As for the bonding
interface 3 specimens of each group were chosen, and
prepared for scanning electron microscopy (SEM). Enamel
and dentin were evaluated separately, data was analyzed
by the ANOVA and Post Test Tukey (p<0.05). Significance
level was 5%.
Results
It could be observed that for both substrates the Clearfil
SE Bond (E: 20.19 MPa; D: 17.61 MPa) was statically
superior than Single Bond (E: 17.21 MPa; D: 15.45 MPa)
(p<0.05). As for the time of restoration, group 2 had the
worst results, in both enamel and dentin. It was observed
that that radiation affected negatively the bonding in
enamel and dentin (p<0.05), however, in the group 4 no
alterations were observed (p<0.05). The predominant
fracture pattern was the adhesive, which had raised its
prevalence according to the radiation. In the MC analyses
there were morphological alteration in enamel and dentin
after the cumulative doses of 40 Gy. It was observed, by
SEM, tags formations and alterations on the hybrid layer.
Conclusion
It could be concluded that RT had affected the
morphological surface of enamel and dentin, and that it
affected the adhesion of the bonding systems, indicating