ESTRO 36 Abstract Book

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S339 ESTRO 36 2017
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Conclusion
The combination of reirradiation and hyperthermia is well
tolerated and results in durable local control. ReRT+HT
should be considered a standard adjuvant treatment
option following surgery for patients with recurrent breast
cancer. Late toxicity might be reduced by decreasing reRT
fraction size and/or avoiding photon-electron abutments.
PO-0657 Breast cancer subtypes and incidence/survival
in patients with brain metastases
Y.C. Tsai1, M.C. Liu2, H.C. Cheng 1, J.J. Jian1, B.L. Yu3,
C.M. Chen 3, N.M. Chu2, C.F. Horng4, M.H. Tsou 5
1 Koo Foundation Sun Yat-Sen Cancer Center, Radiation
Oncology, Taipei, Taiwan
2 Koo Foundation Sun Yat-Sen Cancer Center, Medical
Oncology, Taipei, Taiwan
3 Koo Foundation Sun Yat-Sen Cancer Center, Surgery,
Taipei, Taiwan
4 Koo Foundation Sun Yat-Sen Cancer Center, Clinical
Research Office, Taipei, Taiwan
5 Koo Foundation Sun Yat-Sen Cancer Center, Pathology,
Taipei, Taiwan
Purpose or Objective
Identify incidences and prognosis of breast cancer patients
with brain metastases(BM) by breast cancer subtypes. We
sought to determine whether a high-risk group could be
defined in whom a search of occult BM was justified.
Material and Methods
Information was obtained from the institutional breast
cancer data base. Between 1990 and 2010, 6037 newly
diagnosed stage I to III breast cancer patients were
included in this study to determine the incidence of brain
metastases in different breast cancer subtypes.
Retrospective survival analyses were performed in 136 BM
per breast cancer subtypes. 90 BM patients had detailed
clinical information to define the median time interval
from primary diagnosis to development of brain
metastases. Estrogen receptor (ER), progesterone
receptor (PR), and human epidermal growth receptor-2
(HER2) statuses were tested by immunohistochemical
(IHC) staining, and HER2 FISH analysis conducted for IHC
2+.
Results
With a median follow-up of 80 months. The incidence of
CNS relapse was 2.8%. For stage I, II, III, the BM incidence
was 0.9%, 2.1% and 6.5% respectively. Incidence of BM
were 1% (luminal A), 1.8% (luminal B), 3.9%
(luminal/HER2), 6.5% (HER2 enriched), and 4.6%(triple
negative) respectively. Among 1503 stage III patients, the
Incidence of BM were 2.1% (luminal A), 1.5% (luminal B),
9.9% (luminal/HER2), 13.2% (HER2 enriched), and
12.4%(triple negative) respectively. One year survival with
BM were 40% (luminal A), 46.7% (luminal B), 54.2%
(luminal/HER2), 39.1% (HER2 enriched), and 42.4% (triple
negative) respectively. Three-year survival with BM were
24% (luminal A), 33.3% (luminal B), 9% (luminal/HER2),
6.5% (HER2 enriched), and 7.6% (triple negative)
respectively. The median time interval from primary
diagnosis to development of brain metastases were 99.5
months (luminal A), 58 months (luminal B), 37 months
(luminal/HER2), 24 months (HER2 enriched), and 23
months (triple negative) respectively.
Conclusion
Subtype of breast cancer patients with triple-negative or
HER2-positive had an increased risk for the development
of brain metastases and shorter 3-year survival. The
median time interval from primary diagnosis to
development of brain metastases were shorter (2 years)
for triple negative and HER2-positive patients. Stage III
breast cancer patients with triple-negative or HER2-
positive subtype may deserve a search of occult BM in the
first 2 years after primary diagnosis.
PO-0658 impact of breast radiation therapy on
complications after alloplastic breast reconstruction
C.D.L.G. Chaves1, H.D.A. Carvalho2, T.D.C. Saraiva1, T.T.
Fuzisaki2, G.N. Marta1,3, R. Casagrande4, A. Munhoz4, J.A.
Brasil4, S.R. Stuart2
1Instituto do Câncer do Estado de São Paulo ICESP -
Faculdade de Medicina da Universidade de São Paulo,
Radiation Oncology, Sao Paulo, Brazil
2Faculdade de Medicina da Universidade de São Paulo,
Radiation Oncology, Sao Paulo, Brazil
3Hospital Sírio-Libanês, Radiation Oncology, São Paulo,
Bazil
4Instituto do Câncer do Estado de São Paulo ICESP -
Faculdade de Medicina da Universidade de São Paulo,
Division of Plastic Surgery, Sao Paulo, Brazil
Purpose or Objective
To assess the influence of radiation therapy (RT) in local
complications in breast cancer patients who underwent
breast reconstruction with alloplastic material.
Material and Methods
Between 2009 and 2013, patients with breast cancer who
received alloplastic breast reconstruction with tissue
expander (with included or remote valve), prosthesis-
expander or breast implant were assessed retrospectively.
Patients with at least 2 years of follow-up after the end of
treatment were included. Complications were considered
when any surgical intervention was required. Early
complications, up to three months after surgery and late
complications, after 6 months of the end of the surgery or
RT. Uni and multivariate analysis were performed to
correlate clinical variables with complications.
Results
In the studied period, 251 patients were evaluated. The
mean age was 49.7 years and mean Body Mass Index (BMI)
was 27.5 kg/m2. Most patients (73%) had diabetes mellitus;
35.5% had hypertension and 10.6% were smokers. Disease
was presented in early stage in 78.5%. Modified radical or