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S576

ESTRO 36 2017

_______________________________________________________________________________________________

confirmation by randomized controlled study, HRT should

be considered for the treatment of ESGC.

EP-1053 Analysis of outcomes of Adenoid cystic

Carcinoma of Head and Neck region: Single Institution

Study

M. Rafi

1

, M. Anjanappa

1

, C. Kainickal

1

, P. George

2

, R.

Kumar

1

, R. Kunnambath

1

1

Regional Cancer Centre, Radiation Oncology,

Trivandrum, India

2

Regional Cancer Centre, Epidemiology and biostatistics,

Trivandrum, India

Purpose or Objective

To study the treatment outcomes of Adenoid cystic

carcinoma of the head and neck region.

Material and Methods

The case records of patients who were diagnosed and

treated for adenoid cystic carcinoma of head and neck

region in a tertiary care hospital in India between 2004

and 2011 were retrospectively reviewed. Demographic

data, clinico-pathological details and treatment outcomes

were captured using a structured proforma, for survival

analysis and identification of prognostic factors.

Results

A total of 164 patients reported to the institution with

biopsy proven adenoid cystic carcinoma of the head and

neck region during this period. Out of this, 142 patients

were included in the analysis after excluding the patients

who did not undergo any treatment at this centre.

Out of the 142 patients analyzed, 57.7% were females. The

mean age of presentation was 46.5yrs (Range 16-84 yrs).

The most common site of presentation was oral cavity

(28.2%) followed by paranasal sinus and nasal cavity

(22.5%), and parotid gland (15.5%). A total of 44.4% of

patients had stage I /II disease. Node positivity was seen

in 16 patients (11.2%) and three patients had metastatic

disease at presentation.

Surgery was the primary modality of management in 120

patients(84.5%).Among them 67 patients (47.2%) had

margin positive resection. Most of these were either

unplanned excisions or were paranasal sinus lesions.

Radiotherapy was delivered to 120 patients (84.5%) as a

part of their treatment, with majority being given

adjuvant radiotherapy (100 patients). Curative

radiotherapy was used in 18 patients. Radiotherapy dose

ranged from 60-70 Gy in two Gy equivalent.

Recurrence was recorded in 47 patients (33%); 21 patients

had isolated recurrence in the primary site, 20 had

systemic failure, 5 patients had nodal failure and 1 patient

had systemic and local failure. The mean time for

development of failure was 32 months (Range 1-99months)

for systemic and 44.5 months (Range 5-105months) for

loco-regional site. Of the 18 patients who were given

radical RT, 14 had complete response (77.7%) and among

them eight patients had disease recurrence.

Radiotherapy was given to 13 patients with recurrence,

eight patients underwent surgery, three patients had

chemotherapy and 11 patients were just kept on follow-

up.

The disease free survival at 5 years was 76.9%.

Conclusion

Adenoid cystic carcinomas are relatively rare neoplasms

of salivary glands. A good proportion of these tumours

occur in minor salivary glands as reflected in this analysis.

Surgery remains the preferred primary treatment modality

with a large proportion of patients also getting RT as a

part of their treatment. Along with loco-regional failure,

these tumours also have a propensity for distant

metastasis.

EP-1054 Disease Outcomes following Post-operative

IMRT for Oral Cavity Cancer: A Single Institution

Analysis

A. Michaelidou

1

, M. Lei

1

, T. Guerrero Urbano

1

1

Guy's & St Thomas' NHS Foundation Trust, Oncology- 4th

Floor Bermondsey Wing, London, United Kingdom

Purpose or Objective

The purpose of this study is to analyse survival outcomes

in patients with oral cavity squamous cell carcinoma

(OCSCC) treated with radical surgery and post-operative

IMRT (POIMRT), +/- chemotherapy, at our institution.

Material and Methods

A retrospective analysis was performed of all patients with

OCSCC who received IMRT with radical intent between

March 2010 and March 2016. Data were extracted from

electronic case records, reviewed only by members of the

responsible clinical team. Statistical analysis was done

using IBM SPSS and Microsoft Excel. Estimates of overall

survival (OS), disease-free survival (DFS) and disease

specific survival (DSS) were done using life tables and the

Kaplan-Meier method.

Results

138 patients with OCSCC received IMRT in total. 127 (73-

male, 54-female; mean age-62, range 26-86) were

included in the survival analysis. 9 patients unsuitable for

surgery that had primary IMRT alone, and one patient who

died of aspiration during treatment were excluded. Of the

127 patients analysed, 7 did not complete the prescribed

course of POIMRT (patient choice in 3, clinician decision

because of

toxicity in

4).

Most patients had advanced disease on pathological

staging: AJCC stage IV - 77.2%, n=98; stage III – 15.7%,

n=20; Stage II – 2.4%, n=3; Stage I - 4.7%, n=6. Smoking

history was recorded in 124 patients: 64.5%, n=80 reported

a significant smoking history (smoking at diagnosis or ex-

smokers with >10 pack years).

Standard POIMRT doses were 60Gy in 30# (64.6%, n=82)

and 65-70Gy in 30-33# (24.4%, n=31) for those with

involved margins. Doses of 50-55Gy in 20# were used in

those with significant co-morbidities or a poor

performance status (11.0%, n=14). Concurrent

chemotherapy with cisplatin100mg/m

2

or carboplatin

AUC5 (when cisplatin contra-indicated), 3-4weekly, was

considered in patients with extracapsular spread and/or

involved margin (49.6% n=63) and given to those with no

contra-indications (31.5%, n=40).

Median follow up from the end of treatment was 20.7

months (range 0.9-76.8 months) in all patients. Median

follow in survivors was 30.9 months (range 7.3-76.8

months). At the time of analysis 39 patients had a

confirmed relapse and 52 patients had died (35 disease

related). Mean survival rates were: OS 45.9 months (95%

CI 39.8-52.1); DFS 43.5 months (95%CI 37.5-49.5); DSS 55.4

months (95% CI 49.4-61.3).

One-year survival rates were: OS 74% (95%CI - 66.2 – 81.8);

DFS 74% (95%CI – 66.2 – 81.8); DSS 79% (95%CI – 71.2 – 86.8).

Three-year survival rates were: OS 54% (95%CI - 44.2 –

63.8); DFS 51% (95%CI – 41.2 – 60.8); DSS 66% (95%CI – 56.2

– 75.8).

Conclusion

Our results are consistent with nationally reported survival

data. Ongoing work is carried out to report treatment

related toxicities and identify histopathological factors

that

may

influence prognosis.

EP-1055 A Novel Postoperative Chemoradiotherapy

Protocol versus Conventional CCRT for High-risk SCCHN

Y.T. Shih

1

, W.Y. Wang

2

, C.T. Wu

3

, J.C. Lin

4

1

St. Martin De Porres Hospital, Radiation Oncology

Department, Chiayi, Taiwan

2

Hung Kuang University, Department of Nursing,

Taichung, Taiwan

3

Changhua Show Chwan Memorial Hospital, Department

of Radiation Oncology-, Changhua, Taiwan

4

Taichung Veterans General Hospital, Department of

Radiation Oncology-, Taichung, Taiwan